Pharmaceutical product, in medical bandage form

US4769028A · kind A · utility

Assignees

• LOHMANN GMBH & CO. KG · DE
• Sanol Schwarz GmbH · DE

Inventors

• Hans-Rainer Hoffmann · Neuwied, DE
• Reinhold Meconi · Neuwied, DE
• Michael Wolff · Monheim, DE
• Horst G. Zerbe · Hudson, CA

Key dates

• Filing date: Jul 17, 1986
• Grant date: Sep 6, 1988
• Expiry date: Jul 17, 2006

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K9/7092
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention is related to a pharmaceutical product preferably in medical bandage form, for the controlled release of a therapeutically active agent or several such agents to the skin. The pharmaceutical product of the invention consists of an impermeable backing layer, a particularly composed supersaturated reservoir layer for the therapeutically active agent connected therewith and comprising a polymer matrix wherein the therapeutically active agent is soluble and which is permeable to the active agent, an adhesive layer connected with the reservoir layer and permeable to the active agent, and a cover layer covering and adhering to said adhesive layer and removable therefrom for the use of the pharmaceutical product as transdermal therapeutic system, said reservoir layer for the therapeutically active agent consisting of a multitude of layers wherein the concentration of the therapeutically active agent increases from layer to layer with increasing distance from the adhesive layer, and process for producing such a pharmaceutical product.