Antracycline antineoplastic agents encapsulated in phospholipid vesicle particles and methods for using same for tumor therapy
US4769250A · kind A · utility
67Cited by
9References
18Claims
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Key dates
| Filing date | Oct 26, 1987 |
| Grant date | Sep 6, 1988 |
| Priority date | — |
| Expiry date | Oct 26, 2007 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H15/252
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Formulations consisting of phospholipid bilayer membrane particles made from mixtures of anionic and neutral phospholipids encapsulating anthracycline anti-neoplastic agents, suspended in a low ionic strength aqueous phase, are described. In a preferred embodiment, the particles are in the form of vesicles which comprise daunorubicin, distearoyl phosphatidylglycerol and distearoyl phosphatidylcholine, the mol ratio of daunorubicin to distearoyl phosphatidylglycerol is at least about 1:1.25, and the suspending medium is an aqueous lactose solution containing a small amount of base.
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