Heterocyclic amino compounds

US4769367A · kind A · utility

Assignee

• Glaxo Group Limited · GB

Inventors

• Peter C. Cherry · Harrow, GB
• Adrian J. Pipe · Northolt, GB
• John Kitchin · Harrow, GB
• Alan David Borthwick · London, GB
• Richard J. Coles · Houston, US
• Derek Burn

Key dates

• Filing date: Jun 25, 1986
• Grant date: Sep 6, 1988
• Expiry date: Jun 25, 2006

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D311/66
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of the general formula (I) ##STR1## (wherein R is H, alkyl, alkenyl, alkynyl, cycloalkyl, aralkyl or CHO; and R.sup.1 and R.sup.2 each represents H, fluorine or chlorine); and their salts have selective .alpha..sub.2 -adrenoreceptor antagonist action. The compounds may be prepared by amination of compounds of the general formula (II): ##STR2## (wherein X is a leaving group).