Circulation-active 1,4-dihydropyridine derivatives and use thereas

US4769375A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Horst Meyer
• Gerhard Franckowiak · Wuppertal, DE
• Gunther Thomas · Wuppertal, DE
• Matthias Schramm · Cologne, DE
• Michael Kayser · Hagen, DE
• Martin Bechem · Wuppertal, DE
• Rainer Gross · Wuppertal, DE

Key dates

• Filing date: Jul 25, 1986
• Grant date: Sep 6, 1988
• Expiry date: Jul 25, 2006

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D409/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Circulation-active dihydropyridines of the formula ##STR1## in which R.sup.1 is optionally substituted aryl or heterocyclic, PA1 R.sup.2 is H, NO.sub.2, CN, C.sub.1 -C.sub.8 -alkylsulphonyl, aryl or carboalkoxy, PA1 R.sup.3 is alkyl or aryl, PA1 R.sup.4 is H or alkyl, PA1 X is C.dbd.O or a direct bond, and PA1 n is a number from 1 to 20, or physiologically acceptable salts thereof. A synthesis using morpholines or thiomorpholines is also disclosed.