Tetraoxo compounds and pharmaceutical compositions

US4771044A · kind A · utility

Assignee

• Kali-Chemie Pharma GmbH · DE

Inventors

• Uwe Schoen · Burgdorf, DE
• Wolfgang Kehrbach · Hannover, DE
• Werner Benson · Hannover, DE
• Andreas Fuchs · Aalen, DE
• Michael Ruhland · Hannover, DE

Key dates

• Filing date: Aug 19, 1986
• Grant date: Sep 13, 1988
• Expiry date: Aug 19, 2006

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Tetraoxo compounds of the Formula (I) ##STR1## wherein R.sup.1 is an alkyl, alkenyl, phenylalkyl or cycloalkylalkyl group, PA0 R.sup.2 and R.sup.3 are each independently an alkyl or phenyl group or together denote an alkylene group, PA0 W is a (CH.sub.2).sub.n --Q group, in which n is 2 to 10 and Q is PA1 (a) a displaceable leaving group X, or PA1 (b) Z-R.sup.4, where Z is a 1-piperazinyl group, and R.sup.4 is in position 4, and is hydrogen or a phenyl, substituted phenyl, N-heteroaryl or substituted N-heteroaryl group; and salts and acid addition salts of said compound, and a method for their preparation. Selected compounds of Formula (I) have been found to have central nervous system affecting activity.