Parathyroid hormone antagonists with simplified synthetic methodology
US4771124A · kind A · utility
35Cited by
1References
3Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 26, 1987 |
| Grant date | Sep 13, 1988 |
| Priority date | — |
| Expiry date | May 26, 2007 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to the use of peptide hormone analogues as inhibitors of their respective naturally occurring peptide hormone and methods of synthesis of such analogues. The structure of the peptide hormone analogues is exemplified by parathyroid hormone wherein Trp.sup.23 is substituted by L-Phe or other hydrophobic amino acids such as Leu, Nle, Val, Tyr, beta-napthylalanine and alpha-napthylalanine.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.