Nontoxic pseudomonas aeruginosa polysaccharide-tetanus toxoid and polysaccharide-toxin a conjugate vaccines
US4771127A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Aug 4, 1986 |
| Grant date | Sep 13, 1988 |
| Priority date | — |
| Expiry date | Aug 4, 2006 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Polysaccharide-protein conjugates were synthesized utilizing polysaccharide derived from hydrolyized Pseudomonas aeruginosa lipopolysacharide covalently coupled to either tetanus toxoid or P. aeruginosa toxin A, utilizing a spacer molecule and a coupling agent. Conjugates produced in such a manner possess a molecular weight of greater than 350,000, are nontoxic and non-pyrogenic, and upon immunization of animals induced protective anti-LPS antibody and antibody which neutralizes the lethal effect of tetanus toxin or toxin A. The polysaccharide-tetanus toxoid conjugate and polysaccharide-toxin A conjugate are safe and immunogenic when parenterally administered to humans.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.