Method for controlling emesis caused by chemotherapeutic agents and antiemetic agents useful therein
US4772459A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Sep 9, 1986 |
| Grant date | Sep 20, 1988 |
| Priority date | — |
| Expiry date | Sep 9, 2006 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D207/09
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method for alleviating emesis caused by chemotherapy which comprises administering an antiemetic agent or a pharmaceutically acceptable salt thereof to a patient in conjunction with the administration of a chemotherapeutic agent, said antiemetic agent being represented by the formula (I) ##STR1## wherein Z represents a substituent such as a lower alkyl group, a methoxyethoxymethyl group, or a benzoylmethyl group; or Z in conjunction with the adjacent position represents the atoms necessary to complete a 5 to 7 membered saturated or unsaturated oxygen-containing ring; R represents a hydrogen atom, a halogen atom, a lower alkyl group, a cycloalkyl group, a lower alkoxy group, an amino group, an alkylsulfonyl group, a lower alkyl-substituted amino group, an acylamido group, a sulfamoyl group, a sulfonamido group or a nitro group; n is an integer of 1 to 3; W is a straight chain or branched chain alkylene group of 1 to 4 carbon atoms; and X represents the atoms necessary to complete a 5 or 6 membered ring; said antiemetic agent being administered in an amount and in a manner which alleviates emesis associated with said chemotherapeutic agent; and certain new antiemetic agents useful …
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.