Basic formulations of quinolonecarboxylic acids

US4772605A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Arundev H. Naik · Monheim, DE
• Gerhard Schluter · Wuppertal, DE
• Herbert Voege · Leverkusen, DE
• Klaus Grohe · Odenthal, DE

Key dates

• Filing date: Sep 14, 1987
• Grant date: Sep 20, 1988
• Expiry date: Sep 14, 2007

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P31/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Improvement in the parenteral administration of a carboxylic acid of the formula ##STR1## in which X is N, C--H or C--F, PA1 Z is O or Ch.sub.2, PA1 R.sub.1 is hydrogen, methyl, ethyl or .beta.-hydroxyethyl, PA1 R.sub.2 is cyclopropyl, 2-fluoroethyl or ethyl, PA1 R.sub.3 is hydrogen or methyl, and PA1 R.sub.4 is H or methyl, is achieved through the administration of the basic salt of the acid (I, II). Surprisingly the basic salts are suitable and stable.