High percentage beta-yield synthesis of carbapenem intermediates
US4772683A · kind A · utility
7Cited by
1References
13Claims
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Key dates
| Filing date | Feb 24, 1986 |
| Grant date | Sep 20, 1988 |
| Priority date | — |
| Expiry date | Feb 24, 2006 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D417/12
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Disclosed herein is a novel process using novel silyl enol ether intermediates of the formula ##STR1## to generate novel azetidione thiolester intermediates of the formula ##STR2## which can be used to form 1-.beta.-alkyl carbapenem antibiotics. It has now been discovered that if the R.sup.4 group is selected from a small group of moieties having the formula: ##STR3## an increased .beta.-yield of up to approximately 100% can be obtained.
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