Peptide derivatives
US4775743A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Sep 10, 1986 |
| Grant date | Oct 4, 1988 |
| Priority date | — |
| Expiry date | Sep 10, 2006 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
New peptide derivatives represented by the following general formula EQU R.sub.1 -Pro-Hyp-R.sub.2 wherein R.sub.1 is a hydrophobic radical, R.sub.2 is a hydrophilic radical, Pro is prolyl and Hyp is hydroxyprolyl show more powerful inhibitory action against platelet agglutination than conventional drugs and have potential use as anti-agglutination agent. The peptide derivative can be prepared by condensing a peptide containing a hydrophobic radical with a carboxylic acid containing a hydrophilic radical. The peptide derivative can be used in the form of parenteral injections, tablets, capsules or powder, the typical daily dose being in the range from 1 mg to 500 mg for adults.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.