Heterocyclic derivatives, processes for the use thereof and pharmaceutical compositions containing them

US4777179A · kind A · utility

Assignee

• Glaxo Group Limited · GB

Inventors

• John Bradshaw · Solon, US
• Duncan B. Judd · Ware, GB
• Barry J. Price · London, GB
• John W. Clitherow · Sawbridgeworth, GB
• John MacKinnon · Hertford, GB
• Linda Carey · Royston, GB
• Roger Hayes · Digswell, GB

Key dates

• Filing date: Oct 21, 1985
• Grant date: Oct 11, 1988
• Expiry date: Oct 21, 2005

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D333/42
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention provides compounds of the general formula ##STR1## and physiologically acceptable salts and hydrates thereof, in which one of R.sub.1 and R.sub.2 represents hydrogen, halogen or a C.sub.1-4 alkyl group which may be optionally substituted by hydroxy or C.sub.1-4 alkoxy, and the other represents the group R.sub.4 R.sub.5 NAlk-- in which Alk represents a straight or branched alkylene chain of 1 to 6 carbon atoms; PA1 R.sub.3, which may be in either the 2 or 3-position, represents the ##STR2## where X represents --CH.sub.2 --, --O-- or --S--; n represents zero, 1 or 2; PA1 m represents 2, 3 or 4; and PA1 R.sub.7 represents hydrogen, alkyl, alkenyl, aralkyl, or C.sub.2-6 alkyl substituted by hydroxy or alkoxy; and PA1 R.sub.8 represents hydrogen, alkyl, alkenyl, aralkyl, hydroxyalkyl, acyloxyalkyl, alkoxyalkyl, aryloxyalkyl, aralkyloxyalkyl, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, hydroxy or alkoxy, or the group NR.sub.10 R.sub.11 ; with the provisos that PA1 where R.sub.2 represents the group R.sub.4 R.sub.5 Nalk then R.sub.3 is in the 2-position; PA1 where R.sub.2 represents hydrogen then R.sub.3 is in the 3-position; and PA1 where R.sub.2 represents halogen or C…