Crosslinked hemoglobin of extended shelf life and high oxygen transport capacity and process of preparing same
US4777244A · kind A · utility
40Cited by
2References
6Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 8, 1987 |
| Grant date | Oct 11, 1988 |
| Priority date | — |
| Expiry date | May 8, 2007 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Crosslinked hemoglobin preparations of extended shelf life and high oxygen transport capacity can be made by reducing a hemoglobin solution with an oxygen consuming reducing agent down to an oxygen partial pressure of 0 mbar, then adding an effector, crosslinking with a dialdehyde, reducing with a carbonyl-group-specific reducing agent, circulating through an ultrafilter, and stabilizing the product by adding a reducing agent thereto.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.