10,10-dihydro-10-[(substituted-carbonyl)imino]-10-phe nyl-10H-phenoxaphosphines
US4777290A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jul 27, 1987 |
| Grant date | Oct 11, 1988 |
| Priority date | — |
| Expiry date | Jul 27, 2007 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F9/657163
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Novel 10,10-Dihydro-10-[(substituted carbonyl)imino]-10-phenyl-10H-phenoxaphines of the formula: ##STR1## wherein A is selected from the group consisting of hydrogen and COOR.sub.1, where, when A is hydrogen the compound is in the form of a water soluble salt HnX, where n is an integer 1 or 2 and X is selected from the group consisting of sulfate, trefluoroacetate, bromide and chloride and R.sub.1 is selected from the group consisting of straight or branched chain alkyl(C.sub.1 -C.sub.4), alkenyl(C.sub.2 -C.sub.4), alkynyl(C.sub.2 -C.sub.4), cycloalkyl(C.sub.3 -C.sub.6), cycloalkyl(C.sub.3 -C.sub.6)methyl, benzyl, pyridylmethyl and tetrahydro-3-furanyl; methods for using these compounds for effecting diuresis, treating hypertension and edema and lowering plasma renin activity in mammals; pharmaceutical compositions of matter containing these compounds and processes for their preparation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.