3-oxadiazole and 3-carboxylic acid beta-carboline derivatives, and their use as psychotropic agents

US4778800A · kind A · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Andreas Huth · Berlin, DE
• Ralph Schmiechen · Berlin, DE
• David N. Stephens · Berlin, DE
• Mogens Engelstoft
• Frank Waetjen
• John Bondo Hansen · Avenue Madeleine, DK
• Leif H. Jensen · Copenhagen, DK

Key dates

• Filing date: Nov 13, 1986
• Grant date: Oct 18, 1988
• Expiry date: Nov 13, 2006

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P25/20
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of formula I ##STR1## wherein X is COOR.sup.3 or an oxadiazolyl radical of the formula or PA1 R.sup.2 is H, lower alkyl or cycloalkyl, PA1 R.sup.3 is lower alkyl, PA1 R.sup.4 is hydrogen, lower alkyl or lower alkoxyalkyl, PA1 R.sup.A is -CHR.sup.1 -Z-R.sup.5, PA1 Z is sulfur or oxygen, PA1 R.sup.1 is lower alkyl or optionally substituted phenyl, and R.sup.5 is hydrogen, phenyl or optionally substituted lower alkyl, and wherein each compound can contain 1 or 2 R.sup.A radicals have valuable pharmacological properties.