Substituted 2-amino-2-imidazolines as antifibrillatory agents

US4778807A · kind A · utility

Assignee

• E.I. DU PONT DE NEMOURS AND COMPANY · US

Inventors

• David M. Stout · Vernon Hills, US
• William L. Matier · Libertyville, US
• Lawrence A. Black · Libertyville, US

Key dates

• Filing date: Oct 13, 1987
• Grant date: Oct 18, 1988
• Expiry date: Oct 13, 2007

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D233/48
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Described are compounds of the formula: ##STR1## wherein Y denotes dimethylamino, methylpropynylamino, pyrrolidino, piperidino, or morpholino; R.sub.1 and R.sub.2 independently of each other denote hydrogen or loweralkyl; and X denotes loweralkyl, loweralkoxy, or halo; and n is and integer from 1 to 3 inclusive, or pharmaceutically acceptable salts thereof. The compounds exhibit antiarrhythmic activity without unwanted sympathomimetic effects.