New benzoic acid derivatives, as well as processes for their production and their use as pharmaceuticals

US4778925A · kind A · utility

Assignee

• Klinge Pharma GmbH · DE

Inventors

• Helmut Grill
• Friedemann Reiter · Putzbrunn, DE
• Michael Schliack · Munich, DE
• Roland Loser · Feldafing, DE
• Klaus Seibel · Gräfelfing, DE

Key dates

• Filing date: May 22, 1987
• Grant date: Oct 18, 1988
• Expiry date: May 22, 2007

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P9/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Para substituted benzoic acid derivatives of general formula (1) ##STR1## and their physiologically compatible salts, where R.sup.1 may be H, isopropyl, t-butyl p0 X may be ##STR2## and R.sup.2 may be --OH, --OR', where R' is a linear or branched, saturated or unsaturated C.sub.1 to C.sub.3 alkylmoiety, or a --NHCH.sub.2 COOH-- group, have hypolipedemic activity. They may be obtained by known methods either from the corresponding unsaturated ketones or from saturated hydroxycompounds, where the esterified benzoic acid moiety may be saponified or converted to a carboxymethylamide.