Glycoesters of estradiol and estriol

US4780460A · kind A · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Bernd Dusterlerg · Berlin, DE
• Bernard Acksteiner · Berlin, DE
• Paul-Eberhard Schulze

Key dates

• Filing date: Mar 27, 1986
• Grant date: Oct 25, 1988
• Expiry date: Mar 27, 2006

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07J1/0074
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Glycoesters of estradiol (E.sub.2) and of estriol (E.sub.3) of Formula I EQU (E.sub.2,3)--O--CO--CH.sub.2 --Z (I) wherein PA0 Z is hydroxy or the group --O--CO--R wherein PA1 R is methyl or phenyl, provide a uniform and enduring estrogen level especially when used in the form of an aqueous crystalline suspension.