Preparation process of .alpha.-L-aspartyl-L-phenylalanine methyl ester or hydrochloride thereof
US4780561A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Dec 9, 1987 |
| Grant date | Oct 25, 1988 |
| Priority date | — |
| Expiry date | Dec 9, 2007 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/801
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Disclosed herein is a process for preparing .alpha.-L-aspartyl-L-phenylalanine methyl ester or its hydrochloride from 5-benzyl-3,6-dioxo-2-piperazine acetic acid or its methyl ester, prepared without using L-penylalanine methyl ester which involves problems in its stability, as a raw material. Specifically, the process comprises: bringing 5-benzyl-3,6-dioxo-2-piperazine acetic acid in the presence of methanol or 5-benzyl-3,6-dioxo-2-piperazine acetic acid methyl ester in the presence or absence of methanol into contact with hydrochloric acid; isolating the thereby deposited .alpha.-L-aspartyl-L-phenylalanine methyl ester hydrochloride; and neutralizing said hydrochloride with an alkali as required. Preparation processes of 5-benzyl-3,6-dioxo-2-piperazine acetic acid or its methyl ester are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.