Solid polyvinyl alcohol-based support able to adsorb lipoproteins and its use for the separation of low density lipoproteins present in a liquid, such as blood plasma

US4781838A · kind A · utility

Assignee

• COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES · FR

Inventors

• Genevieve Crassous · Paris, FR
• Gilbert Gaussens · Meudon, FR
• Dominique Duval · Courbevoie, FR
• Maryvonne Nicaise · Le Puy-en-Velay, FR
• Gerard Vergne · Antony, FR
• Sylvaine Hours · Paris, FR

Key dates

• Filing date: Aug 18, 1986
• Grant date: Nov 1, 1988
• Expiry date: Aug 18, 2006

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S210/908
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This support is constituted by a crosslinked polyvinyl alcohol hydrogel, whereof at least part of the --OH groups have been replaced by --OSO.sub.3 H groups. The crosslinked polyvinyl alcohol hydrogel comprises 70 to 95% by weight of chains derived from polyvinyl alcohol and 5 to 30% by weight of chains derived from crosslinking monomers, such as triethylene glycol diacrylate and tetraethylene glycol triacrylate. These supports can be used for the ex-vivo purification of the blood plasma in pocket 31 or 33.