Novel intermediates for the synthesis of cephalosporins

US4782162A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Michael Boberg · Wuppertal, DE
• Paul Naab · Bad Reichenhall, DE
• Samir Samaan · Wuppertal, DE

Key dates

• Filing date: Jun 9, 1986
• Grant date: Nov 1, 1988
• Expiry date: Jun 9, 2006

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D277/20
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The new compounds of the formula ##STR1## in which Acyl is alkylcarbonyl optionally substituted by halogen or aryl, or arylcarbonyl, which is substituted by lower alkoxy, halogen or nitro, PA0 R.sup.1 is an alkyl or alkenyl radical, and PA0 R.sup.4 is an optionally substituted branched or straight-chain C.sub.1 -C.sub.6 -alkyl radical or a cycloalkyl radical, are produced by reacting a 2-halogenoacetylacrylic acid ester of the formula ##STR2## with an acylthiourea of the formula ##STR3## The reaction can be conducted in aqueous DMF, substantially pure Z-isomer selectively crystallizing out.