Treatment of emesis, nausea and vomiting

US4783478A · kind A · utility

Assignee

• Beecham Group plc · GB

Inventors

• Gordon Wootton · Sawbridgeworth, GB
• Gareth J. Sanger · Sawbridgeworth, GB

Key dates

• Filing date: Jul 9, 1987
• Grant date: Nov 8, 1988
• Expiry date: Jul 9, 2007

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A method of treatment of emesis, anxiety and/or IBS in mammals, including humans, which method comprises administering an effective amount of a compound of formula (I) or (II) or a pharmaceutically acceptable salt thereof: EQU Ar--CO--Y--Z (I) wherein Ar is a group of formula (a): ##STR1## wherein: R.sub.1 and R.sub.2 are independently selected from hydrogen, halogen, C.sub.1-6 alkyl, C.sub.1-4 alkoxy, hydroxy, amino optionally substituted by one or two C.sub.1-4 alkyl groups, thiol, C.sub.1-4 alkylthio; X is CH.sub.2, NR.sub.3, --O-- or --S-- wherein R.sub.3 is hydrogen, C.sub.1-4 alkyl, C.sub.3-5 alkenyl, phenyl or phenyl C.sub.1-4 alkyl; PA0 or Ar is a group of formula (b): ##STR2## wherein R.sub.4 to R.sub.7 are independently hydrogen, halogen, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, hydroxy, amino optionally substituted by one or two C.sub.1-4 alkyl, by C.sub.1-4 alkanoylamino or pyrrolyl, one of R.sub.4 to R.sub.7 being other than hydrogen; PA0 Y is --O-- or --NH--; and PA0 Z is a group of formula (c), (d) or (e): ##STR3## wherein n is 2, 3 or 4; PA0 R.sub.8 is hydrogen, C.sub.1-7 alkyl, C.sub.3-5 alkenyl or phenyl C.sub.1-4 alkyl optionally substituted by one or two halogen, C.su…