Resolution of enantiomers of 2-(phenyl or phenoxy/propionic acids using optically active alkanolamines
US4786731A · kind A · utility
6Cited by
4References
6Claims
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Key dates
| Filing date | Aug 5, 1987 |
| Grant date | Nov 22, 1988 |
| Priority date | — |
| Expiry date | Aug 5, 2007 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D241/44
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A method for the chromatographic resolution and analysis of the enantiomers of 2-(phenyl or phenoxy)propionic acids or the C.sub.1 -C.sub.4 alkyl esters thereof which comprises converting a racemic or partially resolved mixture of said 2-(phenyl or phenoxy)propionic acids or the C.sub.1 -C.sub.4 alkyl esters thereof to a pair of diastereomeric 2-amino-1-alkanol derivatives by reaction with an optically active 2-amino-1-alkanol, and analyzing the diastereomeric mixture by gas chromatography.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.