Method of treating amyotrophic lateral sclerosis with dipeptide derivatives and pharmaceutical compositions for use therein

US4788179A · kind A · utility

Assignee

• Gruenenthal GmbH · DE

Inventors

• Leopold Flohe · Roetgen, DE
• Hans Barth · Aachen, DE

Key dates

• Filing date: Dec 11, 1985
• Grant date: Nov 29, 1988
• Expiry date: Dec 11, 2005

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P25/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A method of treating patients suffering from amyotrophic lateral sclerosis (ALS) by administering dipeptide derivatives of the formula ##STR1## wherein R.sub.1 is hydrogen, a lower alkyl group, cyclohexyl or benzyl; Z is one of the groups ##STR2## wherein if Z is a group (a), R.sub.2 and R.sub.3 together represent an additional bond between the carbon atoms bearing R.sub.2 and R.sub.3, or if Z is a group (b), R.sub.2 is hydrogen; R.sub.4 and R.sub.5 are hydrogen or lower alkyl, or R.sub.5 may also be phenyl; and R.sub.6 is hydrogen or methyl; hydrates or pharmaceutically acceptable acid additions salts thereof. Pharmaceutical compositions containing effective ALS symptom counteracting amounts of such dipeptide derivatives may be administered by infusion, injection, orally, rectally or percutaneously.