Fluorooxirane carboxylates as hypoglycemic agents
US4788306A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Aug 21, 1987 |
| Grant date | Nov 29, 1988 |
| Priority date | — |
| Expiry date | Aug 21, 2007 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D303/48
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
There are disclosed compounds of the formula ##STR1## wherein R.sup.1 and R.sup.2 are each, independently, hydrogen, hydroxy, lower alkyl, lower alkoxy, haloloweralkyl, haloloweralkyl sulfonyl, halo or nitro; PA1 R.sup.3 is hydrogen, lower alkyl, or aryl of 7-12 carbon atoms; ##STR2## A is --CH.sub.2 --, --O-- or --S--; m is 1-8; PA1 n is 0-7, with the proviso that m+n.ltoreq.8; or a pharmacologically acceptable salt thereof, and their use as fatty acid oxidation inhibitors possessing a significantly reduced potential for impairment of normal cardiac function, and having particular utility in the treatment of glucose and fatty acid metabolism disorders, such as diabetes.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.