1.alpha.,7.alpha.-dithio-substituted spirolactones, processes for their preparation, and their use as medicines

US4789668A · kind A · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Klaus Nickisch · Berlin, DE
• Henry Laurent
• Dieter Bittler · Berlin, DE
• Rudolf Wiechert · Berlin, DE
• Wolfgang Losert

Key dates

• Filing date: Oct 17, 1986
• Grant date: Dec 6, 1988
• Expiry date: Oct 17, 2006

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07J53/008
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The disclosure relates to novel 1.alpha.,7.alpha.-dithio-substituted spirolactones of general Formula I ##STR1## wherein R.sup.1 is C.sub.1-3 -alkyl and C.sub.1-3 -acyl and PA0 R.sup.2 is hydrogen, C.sub.1-3 -alkyl and C.sub.1-3 -acyl, to their preparation, and to their use as medicinal agents. The compounds of this invention exhibit anti-aldosterone activity and show the profile of effectiveness of a pro-drug.