Conjugate constituted from a wall adhesin of S. mutans of proteinic nature and from a polysaccharide of S. mutans, its preparation and its use particularly in anti-caries vaccines

US4789735A · kind A · utility

Assignees

• UNIVERSITÉ CATHOLIQUE DE LOUVAIN · BE
• Institut National de la Sante et de la Recherche Medicale (INSERM) · FR

Inventors

• Robert Frank · Aachen, DE
• Jean-Paul Klein · Saint-Fons, FR
• Fabienne Ackermans · Brussels, BE
• Herve Bazin · Brussels, BE

Key dates

• Filing date: May 13, 1986
• Grant date: Dec 6, 1988
• Expiry date: May 13, 2006

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S530/806
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The conjugate according to the invention is constituted by a wall adhesin of Streptococcus mutans, of a proteinic nature, capable of binding the components of saliva, or an active fraction of such a protein, covalently coupled to a Streptococcus mutans polysaccharide, or to a fraction of such a polysaccharide. Preferably, the adhesin is constituted by a single polypeptide chain having a molecular weight of about 74,000; it is common to the different serotypes of Streptococcus mutans where it has a crossed antigenicity; and it is capable of interacting with the salivary glycoproteins and polysaccharide derived from the same serotype of S. mutans, particularly serotype f. Use for the preparation of immunogenic compositions, particularly for the preparation of vaccines against dental caries.