Analytical device and method utilizing a piezoelectric crystal biosensor
US4789804A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Sep 17, 1986 |
| Grant date | Dec 6, 1988 |
| Priority date | — |
| Expiry date | Sep 17, 2006 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S436/829
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A bio-sensor is mounted in a container and comprised of a receptor for selectively reacting with a specific biochemical substance in a sample liquid held in the container to bind thereon the specific biochemical substance and a resonator integrated with the receptor for detecting the amount of the specific biochemical substance bound to the receptor in terms of a resonant frequency shift of the resonator. A measuring circuit is connected to the sensor for measuring the resonant frequency shift of the resonator within the container; a switching valve operates during the reaction of the receptor with the specific biochemical substance to charge a sample liquid into the container to contact the sample liquid with the receptor to thereby effect the reaction and operates during the measurement of the resonant frequency shift to replace the sample liquid by a buffer liquid in the container to immerse the sensor in the buffer liquid to thereby prevent a fluctuation of the resonant frequency shift.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.