Depyrogenation of clinical albumin
US4791191A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Nov 12, 1987 |
| Grant date | Dec 13, 1988 |
| Priority date | — |
| Expiry date | Nov 12, 2007 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K14/765
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A simple method for the depyrogenation of clinical albumin is disclosed. It includes mixing the pyrogenic clinical albumin with human plasma, followed by a two-step albumin method reported previously by this inventor. The depyrogenated albumin, in the form of ethanol precipitate, can then be processed into clinical albumin according to the conventional procedures. This simple process not only results in the depyrogenation of the endotoxin--contaminated albumin, but also recovers the albumin which is present in the added plasma. The overall albumin yield is greater than 90% as calculated from the starting pyrogenic albumin and the albumin present in the added plasma.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.