Naphthalene anti-psoriatic agents

US4792556A · kind A · utility

Assignee

• Syntex (U.S.A.) LLC · US

Inventors

• D. V. Krishna Murthy · Cupertino, US
• Michael C. Venuti · San Francisco, US
• John M. Young · Palm Harbor, US

Key dates

• Filing date: Apr 28, 1986
• Grant date: Dec 20, 1988
• Expiry date: Apr 28, 2006

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C69/635
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Psoriasis in mammals is relieved by topically administering naphthalenes of the formula: ##STR1## wherein: R.sup.1 and R.sup.2 are the same and are lower alkoxy or optionally substituted phenoxy, PA0 R.sup.3 is lower alkyl, lower alkoxy, or halo and m is 0, 1 or 2 or R.sup.3 is optionally substituted phenyl, optionally substituted phenyl lower alkyl, optionally substituted phenyl lower alkoxy, amino, lower alkylamino, lower dialkylamino, cyano, or S(O).sub.n R wherein R is lower alkyl; optionally substituted phenyl; optionally substituted phenyl lower alkyl; or optionally substituted heterocyclic aryl of three to nine ring atoms containing one or two heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur, and the pharmaceutically acceptable acid addition salts thereof; and m is 1 and n is 0, 1 or 2; PA0 at least one of X or Y is C(O)W and the other X or Y is different and is hydrogen, C(O)W or R.sup.4 wherein PA0 W is alkyl of one to seven carbon atoms, optionally substituted phenyl or optionally substituted benzyl; and PA0 R.sup.4 is lower alkyl or optionally substituted phenyl-lower-alkyl.