Macromolecular platinum antitumor compounds
US4793986A · kind A · utility
27Cited by
5References
11Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 25, 1987 |
| Grant date | Dec 27, 1988 |
| Priority date | — |
| Expiry date | Feb 25, 2007 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P35/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A composition comprising a pharmaceutically acceptable polysaccharide carrier which has been chemically activated and then linked to platinum in either a +2 or +4 oxidation state through a bidentate oxygen-containing ligand including an amine group coupled to the activated polysaccharide. The composition may be used to link platinum metal remotely to a monoclonal antibody via the oxygen-containing ligand and the polysaccharide carrier such as dextran. The composition is optionally radiolabeled.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.