Dihydropyridine preparations containing .beta.-blockers

US4794111A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Ulrich Posanski · Glückstadt, DE
• Rainer Gross · Wuppertal, DE
• Stanislav Kazda · Wuppertal, DE
• Gerhard Schluter · Wuppertal, DE
• Matthias Schramm · Cologne, DE

Key dates

• Filing date: Sep 19, 1986
• Grant date: Dec 27, 1988
• Expiry date: Sep 19, 2006

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K31/535
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

An antihypertensive and antianginal combination comprising (A) 0.1 to 10 parts by weight of an asymmetrical dihydropyridine of the formula ##STR1## in which R.sup.1 and R.sup.5 each independently is methyl, hydroxymethyl or cyano, PA1 R.sup.2 and R.sup.4 are always different from one another and each independently is alkyl with 1 to 10 carbon atoms optionally substituted by alkoxy with 1 to 4 carbon atoms, fluorine, chlorine or N-methyl-benzylamino, PA1 R.sup.3 is nitro, chlorine, trifluoromethyl, or .dbd.N--O--N.dbd., and n is 1 or 2, and (B) about 10 to 200 parts by weight of a .beta.-blocker preferably without a local anesthetic action.