Synthesis of tumor antigenic determinant
US4794176A · kind A · utility
9Cited by
2References
4Claims
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Key dates
| Filing date | Oct 15, 1986 |
| Grant date | Dec 27, 1988 |
| Priority date | — |
| Expiry date | Oct 15, 2006 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H15/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Processes are provided for the synthesis of the human T-antigenic determinant 2-acetamido-2-deoxy-3-O-(.beta.-D-galactopyranosyl)-.alpha.-D-galactopyran oside containing an .alpha.-O-glycosidically linked bridging arm O--(CH.sub.2).sub.n COR. The determinant is coupled to carrier molecules to form artifical T-antigens, and to insoluble supports to form T-immunoadsorbents. The artificial T-antigen is shown to elicit a delayed type hypersensitivity reaction as a diagnostic for the presence of cancer in humans.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.