Process for the preparation of imidazopyridines
US4794185A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 26, 1987 |
| Grant date | Dec 27, 1988 |
| Priority date | — |
| Expiry date | Jun 26, 2007 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D471/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process for the preparation of an imidazopyridine which is a compound of formula (I) ##STR1## in which: Y denotes hydrogen, a halogen or a C.sub.1-4 alkyl group; PA1 X.sub.1 and X.sub.2 denote, independently of each other, hydrogen, a halogen or a C.sub.1-4 alkoxy, C.sub.1-6 alkyl, CF.sub.3, CH.sub.3 S, CH.sub.3 SO.sub.2 or NO.sub.2 group; and PA1 R.sub.1 and R.sub.2 denote, independently of each other, hydrogen or a C.sub.1-5 alkyl group, with the proviso that R.sub.1 and R.sub.2 do not both denote hydrogen, PA2 or a salt thereof; PA2 which process comprises reacting a compound of formula (V) ##STR2## wherein Y, X.sub.1, X.sub.2, R.sub.1 and R.sub.2 are as defined above, with a reducing agent and if desired converting the resulting compound of formula (I) into a salt, together with intermediates of formulae: ##STR3## The final products have useful pharmacological properties, e.g. as anxiolytics.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.