Certain unsymmetrical quinolinyl ethers having anti-inflammatory and anti-allergic activity

US4794188A · kind A · utility

Assignee

• USV Pharmaceutical Corporation · US

Inventors

• John H. Musser · Alameda, US
• Utpal R. Chakraborty · Flemington, US

Key dates

• Filing date: Dec 19, 1985
• Grant date: Dec 27, 1988
• Expiry date: Dec 19, 2005

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D333/56
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of the formula: EQU Ar.sub.1 -X-Ar-Z-(R).sub.n' and salts thereof, wherein PA1 Ar.sub.1 is a nitrogen, sulfur or oxygen heterocyclic ring; PA1 Ar is a phenyl ring or a nitrogen, oxygen or sulfur heterocyclic ring; PA1 Ar and Ar.sub.1 may be fully substituted or less than fully substituted with H, CH.sub.3, lower alkyl, aryl, aralkyl, halo, hydroxy, lower alkoxy, CF.sub.3, carboxy, alkylcarboxy, arylcarboxy, alkylcarbalkoxy, alkanoyl, formyl, oxo, nitrilo, amino, aminoalkyl, alkylamine, carboxamide, aryloxy, nitro, sulfonyl, sulfonamide, thio, alkylthio, hydroxyalkyl or oxyalkylcarbalkoxy; PA1 X= ##STR1## of up to 2 carbon atoms in the principal chain and up to a total of 4 carbon atoms, ##STR2## Z is an alkylene chain containing up to 10 carbon atoms in the principal chain and a total of up to 12 carbon atoms and from 0 to 2 double bonds and the said alkylene chain may be attached to Ar through an oxygen, sulfur or amino nitrogen atom, and when n'=2, one of the R substituents may be halogen on an omega carbon of the alkylene chain Z; PA1 when n'=1, R is a substituent attached to one of the carbon atoms of Z selected from the group consisting of .dbd.O, OR.sub.3, SR.sub.3,…