Bisarylamines

US4795757A · kind A · utility

Assignee

• Rorer Pharmaceutical Corporation · US

Inventors

• John R. Regan · Princeton, US
• Jeffrey N. Barton · Philadelphia, US
• John T. Suh · Greenwich, US
• Jerry W. Skiles · Tuckahoe, US

Key dates

• Filing date: Nov 20, 1986
• Grant date: Jan 3, 1989
• Expiry date: Nov 20, 2006

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D217/02
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of the formula: ##STR1## and pharmaceutically acceptable salts thereof, wherein: Ar is phenyl, naphthyl, heteroaryl, indole, or fused arylcycloalkyl optionally substituted with hydroxy, halo, CF.sub.3, NO.sub.2, C.sub.1-6 alkyl, C.sub.1-6 alkoxy or aryloxy; PA0 A and A' are each hydrogen, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, hydroxy or aryloxy; PA0 X is cyano, nitro, COOR, SR, SOR or SOOR; PA0 R is H, C.sub.1-6 alkyl or aryl; PA0 n n' and n" are each 0 to 4; and PA0 m, m' and m" are each 1 to 4, have calcium channel blocking activity.