Functionalized intermediate for the synthesis of alpha-functionalized derivatives and labeled conjugates of procaimamide and NAPA
US4795828A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Sep 25, 1986 |
| Grant date | Jan 3, 1989 |
| Priority date | — |
| Expiry date | Sep 25, 2006 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/9453
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Procainamide and N-acetylprocainamide (NAPA) immunogens, antibodies prepared therefrom, labeled conjugates, synthetic intermediates, and the use of such antibodies and labeled conjugates in immunoassays for determining the respective drugs. The immunogens comprise the drugs coupled at the .alpha.-position of the amide side chain to an immunogenic carrier material. The labeled conjugates and synthetic intermediates similarly are .alpha.-position derivatives of the drugs or precursors thereof. The antibodies and labeled conjugates are particularly useful in homogeneous nonradioisotopic immunoassays for measuring the respective drugs in biological fluids such as serum.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.