Piperazine compounds and antithrombotic pharmaceutical composition comprising the same
US4797399A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Dec 23, 1986 |
| Grant date | Jan 10, 1989 |
| Priority date | — |
| Expiry date | Dec 23, 2006 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D513/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates to N-containing fused heterocyclic compounds of the formula: ##STR1## wherein R.sub.1 and R.sub.2 are each hydrogen, halogen, aryl, lower alkyl, halo (lower) alkyl or nitro, PA0 R.sub.3 is lower alkylene, PA0 R.sub.4 and R.sub.5 are each lower alkylene, PA0 X is CH or N, PA0 Y is S, O, NH, C.dbd.N--OH or CO, PA0 Z is O or NH, and PA0 A is hydrogen, nitroso, amidino, a group of ##STR2## wherein R.sub.6 and R.sub.7 are each hydrogen, lower alkyl, acyl, or lower alkaneimidoyl which may be substituted with esterified carboxy, or a group of the formula: EQU --N.dbd.R.sub.8, wherein R.sub.8 is lower alkylidene which may be substituted with aryl optionally substituted with suitable substituent(s). The compounds are useful for treatment of thrombosis, inflammation, or allergic disease.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.