1-hydroxy-2-pyridones, a process for their preparation, and medicaments which contain them, and intermediates formed in the preparation of the 1-hydroxy-2-pyridones

US4797409A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Gerhard Lohaus · Kelkheim, DE
• Walter Dittmar · Hofheim, DE
• Heinz Hanel · Oberursel, DE
• Wolfgang Raether
• Dieter Reuschling · Rockenberg, DE
• Bengt-Thomas Grobel · Idstein, DE

Key dates

• Filing date: Apr 16, 1987
• Grant date: Jan 10, 1989
• Expiry date: Apr 16, 2007

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D309/38
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

New 1-hydroxy-2-pyridones of the general formula I ##STR1## in which R.sup.1, R.sup.2 and R.sup.3, which are identical or different, denote hydrogen or lower alkyl having 1-4 carbon atoms, R.sup.1 and R.sup.3 preferably being hydrogen, and R.sup.2 preferably being methyl, PA0 X denotes S or, preferably, O, PA0 Y denotes hydrogen or up to 2 halogen atoms, namely chlorine and/or bromine, PA0 Z denotes a single bond or the bivalent radicals O, S, --CR.sub.2 -- (R=H or C.sub.1 -C.sub.4 -alkyl) or other 2-valent radicals with 2-10 carbon and, optionally, oxygen and/or sulfur atoms linked to form a chain, it being obligatory when the radicals contain 2 or more oxygen and/or sulfur atoms for the latter to be separated by at least 2 carbon atoms, and it being possible for 2 adjacent carbon atoms also to be linked together by a double bond, and the free valencies of the carbon atoms being saturated by H and/or C.sub.1 -C.sub.4 -alkyl groups, PA0 Ar denotes an aromatic ring system which has up to two rings and can be substituted by up to three radicals from the group comprising fluorine, chlorine, bromine, methoxy, C.sub.1 -C.sub.4 -alkyl, trifluoromethyl and trifluoromethoxy, are prepared b…