Process for the preparation of 3-(2'-fluorophenyl)pyridine
US4797490A · kind A · utility
2Cited by
8References
8Claims
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Key dates
| Filing date | Sep 15, 1986 |
| Grant date | Jan 10, 1989 |
| Priority date | — |
| Expiry date | Sep 15, 2006 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D213/26
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
6-Fluoro-7-pyridylquinolone carboxylic esters and acids having antibacterial activity are prepared by coupling of a 2-fluorophenyl-metallic compound with a pyridyl bromide or iodide in the presence of a transition metal catalyst, nitrating and hydrogenating the pyridyl-2-fluorophenyl compound formed, introducing a substituent on the nitrogen of the amine formed, and cyclizing after reacting with a dialkyl or dibenzyl ethoxymethylene malonate to form a 6-fluoro-7-pyridyl-1,4-dihydroquinol-4-one 3-carboxylate, and hydrolyzing to the corresponding acid.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.