Process for preparation of azetidinone derivatives
US4798890A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 21, 1988 |
| Grant date | Jan 17, 1989 |
| Priority date | — |
| Expiry date | Apr 21, 2008 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D205/09
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process for preparing an azetidinone derivative represented by the formula ##STR1## wherein R.sup.1 is hydrogen, halogen or lower alkoxy, R.sup.2 is hydrogen, halogen, lower alkoxy, amino or a group ##STR2## (in which R.sup.5 is substituted or unsubstituted phenyl, substituted or unsubstituted phenylmethyl, substituted or unsubstituted phenoxymethyl, or substituted or unsubstituted benzoyl), or R.sup.1 and R.sup.2, when taken together, are carbonyl, R.sup.3 is substituted or unsubstituted phenyl, and R.sup.4 is hydrogen, optionally substituted hydrocarbon residue or acyl, silyl, sulfonyl or phosphonyl derived from inorganic acid or organic acid, the process comprising reacting a dithioazetidinone derivative represented by the formula ##STR3## wherein R.sup.1, R.sup.2 and R.sup.4 are as defined above and R.sup.9 is substituted or unsubstituted, nitrogen-containing aromatic heterocyclic residue with a compound represented by the formula EQU R.sup.3 SO.sub.2 H (VII) wherein R.sup.3 is defined above.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.