5-methylthio-3-hydroxybenzo [b]thiophene-2-carboxamide derivatives as cyclooxygenase and lipoxygenase inhibitors
US4800211A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Aug 18, 1986 |
| Grant date | Jan 24, 1989 |
| Priority date | — |
| Expiry date | Aug 18, 2006 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D333/70
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
3-Hydroxybenzo[b]thiophene-2-carboxamide derivatives have been prepared by: PA0 (1) treating a substituted 2-halobenzoate with a thioacetamide. PA0 (2) treating a substituted thiosalicylate with an appropriately substituted haloacetamide; and PA0 (3) further synthetic modification of compounds prepared above. These compounds have been found to be effective inhibitors of both cyclooxygenase and lipoxygenase and thereby useful in the treatment of pain, fever, inflammation, arthritic conditions, asthma, allergic disorders, skin diseases, cardiovascular disorders, psoriasis, inflammatory bowel disease, glaucoma or other prostaglandins and/or leukotriene mediated diseases.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.