Pharmaceutical formulation and process for its preparation

US4801455A · kind A · utility

Assignee

• Behringwerke Aktiengesellschaft · DE

Inventors

• Paul H. List · Marburg, DE
• Peter C. Schmidt · Leverkusen, DE
• Klaus-Jurgen Steffens · Rheinbach, DE
• Harald Perschbacher · Bad Homburg vor der Höhe, DE
• Hans Kraemer · Marburg, DE
• Hans H. Sedlacek · Marburg, DE

Key dates

• Filing date: Jul 9, 1987
• Grant date: Jan 31, 1989
• Expiry date: Jul 9, 2007

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K9/113
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A pharmaceutical formulation for the parenteral, in particular intravenous, administration of sparingly soluble substances is obtained when the very finely ground substance, with a maximum particle diameter of 3 .mu.m, is dispersed in an oil phase which contains emulsifier, and this mixture is emulsified with water for injection, is rendered isotonic and is homogenized using a high-pressure homogenizer, so that the resultant product is a solid/liquid/liquid disperse system.