Water soluble zanthylium derivative substrates
US4801534A · kind A · utility
6Cited by
5References
13Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 18, 1987 |
| Grant date | Jan 31, 1989 |
| Priority date | — |
| Expiry date | Jun 18, 2007 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2400/40
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Water soluble xanthylium derivative substrates of rhodamine 110 and rhodol permit spectrophotometric and fluorescent measurements of trypsin-like enzymes without the addition of organic solvent additives and/or special water solubilizing agents. These novel substrates exhibit increased sensitivity for determining low levels of activity of trypsin-like enzymes such as proteolytic enzymes, cofactors, activators, antiactivators, and inhibitors. These substrates can be substituted for fibrinogen to monitor the pathways of blood coagulation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.