Method of inhibiting inflammatory response

US4801612A · kind A · utility

Assignee

• The Regents of the University of California · US

Inventors

• Edward T. Wei · Berkeley, US
• Juliann G. Kiang · Benicia, US

Key dates

• Filing date: Jul 3, 1986
• Grant date: Jan 31, 1989
• Expiry date: Jul 3, 2006

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/2228
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Many malignant neoplasias are treated by radiation therapy which can result in painful inflammation of the covering skin and/or mucosal membranes. Similarly, skin disorder patients receiving U.V. treatment may experience an inflammatory response. Certain neuropeptides have been discovered to have the unusual properties of preventing, or inhibiting, the edema and protein extravasation of skin and mucosal membrane injuries due to thermal or radiation assault or exposure to trauma or noxious agents. A method for inhibiting an inflammatory response in the skin or mucosal membranes of a patient is provided in which a therapeutically effective amount of a neuropeptide, such as Corticotropin Releasing Factor ("CRF") or its analogs, is administered.