Process for the produciton of 2-chloroacetoacetic acid amides

US4801750A · kind A · utility

Assignee

• LONZA LTD · CH

Inventors

• Leander Tenud · Visp, CH
• Raimund Miller · Hackensack, US
• Barry Jackson · Brig, CH

Key dates

• Filing date: Mar 24, 1982
• Grant date: Jan 31, 1989
• Expiry date: Mar 24, 2002

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C51/58
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Process for the production of 2-chloroacetoacetic acid amides. Diketene is converted at a temperature of +30.degree. to -40.degree. C. with the help of hydrogen chloride into acetoacetic acid chloride. Chlorine is introduced into the mixture at a temperature of +30.degree. to -40.degree. C., whereby 2-chloroacetoacetic acid chloride is formed. The latter is converted into the corresponding amide at a temperature of +50.degree. to -40.degree. C. by reaction with a N-compound having the formula: ##STR1## wherein (i) R=R'=H, or PA0 (ii) R=R'=alkyl, substituted alkyl, aryl, substituted aryl, alkyl aryl, substituted alkyl aryl, alkoxy aryl, substituted alkoxy aryl, alkoxy alkyl or substituted alkoxy alky, or PA0 (iii) R=H, and R'=alkyl, substituted alkyl, aryl, substituted aryl, alkyl aryl, substituted alkyl aryl, alkoxy aryl, substituted alkoxy aryl, alkoxy alkyl or substituted alkoxy alkyl.