Novel androstane-17.beta.-carboxylic acid esters
US4804656A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 3, 1986 |
| Grant date | Feb 14, 1989 |
| Priority date | — |
| Expiry date | Apr 3, 2006 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07J31/006
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention refers to compounds having anti-inflammatory activity characterized by the formula ##STR1## or a stereoisomeric component thereof, in which formula X.sub.1 represents a hydrogen, chlorine, bromine or fluorine atom; PA0 X.sub.2 represents a hydrogen, chlorine, bromine or fluorine atom; PA0 R.sub.1 represents a .beta.-hydroxy group, a .beta.-chlorine atom or an oxo group; PA0 R.sub.2 represents a hydrogen atom, a methylene group or an .alpha.- or .beta.-methyl group; PA0 R.sub.3 represents a hydrogen atom or an acyl group of 1 through 8 carbon atoms; PA0 R.sub.4 represents a hydrogen atom, a (C.sub.1 -C.sub.5) alkyl group or a phenyl group; PA0 R.sub.5 represents a hydrogen atom, a (C.sub.1 -C.sub.5) alkyl group or a phenyl group; PA0 Y represents either CR.sub.7 R.sub.8, O, S or NR.sub.9, where R.sub.7, R.sub.8 and R.sub.9 are selected from hydrogen or from straight or branched hydrocarbon chains having 1-8 carbon atoms or from a phenyl group. PA0 R.sub.6 represents a hydrogen; a methyl group; a phenyl or an alkenyl or cycloalkylene group optionally substituted by alkyl, nitro, carboxy, alkoxy, halogen, cyano, carbalkoxy and trifluoromethyl group(s); a (C.sub.1 -C.sub.…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.