Circulation-active 4-aminoaryldihydropyridine lactones

US4804667A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Siegfried Goldmann · Wuppertal, DE
• Matthias Schramm · Cologne, DE
• Rainer Gross · Wuppertal, DE
• Gunther Thomas · Wuppertal, DE
• Martin Bechem · Wuppertal, DE
• Michael Kayser · Hagen, DE

Key dates

• Filing date: Dec 22, 1986
• Grant date: Feb 14, 1989
• Expiry date: Dec 22, 2006

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P9/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

4 Aminoaryldihydropyridines of the formula ##STR1## in which R.sup.1 is hydrogen or an organic radical, preferably methyl or ethyl, PA0 R.sup.2 is hydrogen, C.sub.1 -C.sub.5 -alkyl, --CN, --NH.sub.2, --CH.sub.2 or --CH.sub.2 OH, preferably methyl, PA0 R.sup.3 is hydrogen or alkyl, preferably hydrogen, PA0 Y is --CO-- or --SO.sub.2 --, and PA0 R.sup.4 is an organic radical, or PA0 Y--R.sup.4 is hydrogen, and physiologically acceptable salts thereof, are circulation-active and effective for improving myocardial contractility, for raising blood pressure, for lowering blood sugar, for reducing mucosal swelling and for controlling the salt and fluid balance.