Therapeutic compositions

US4806358A · kind A · utility

Assignee

• THE BOOTS COMPANY PLC · GB

Inventors

• Karrar Ahmad Khan · Nottingham, GB
• John F. Lampard · Mansfield, GB

Key dates

• Filing date: Oct 31, 1986
• Grant date: Feb 21, 1989
• Expiry date: Oct 31, 2006

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P29/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Novel pharmaceutical powder and tablet compositions comprise ibuprofen or a pharmaceutically acceptable salt thereof, a pharmaceutically acceptable effervescent couple that produces carbon dioxide in the presence of water, a pharmaceutically acceptable surfactant and a pharmaceutically acceptable water-insoluble hydrophilic polymer. Preferred hydrophilic polymers are microcrystalline cellulose and croscarmellose sodium. Especially preferred are such compositions which have a saccharide dispersed therein. The incorporation of the saccharide, for example sucrose, lactose, dextrose or sorbitol, enhances the stability of the compositions.