Piperazinyl-substituted pyridine and imidazole anti-arrhythmic agents
US4806536A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Feb 2, 1987 |
| Grant date | Feb 21, 1989 |
| Priority date | — |
| Expiry date | Feb 2, 2007 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P9/06
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A series of novel 4-substituted piperazinyl-pyridine and 4-substituted piperazinyl-imidazole compounds have been prepared, including their pharmaceutically acceptable salts, wherein the 4-substituent is a lower phenylalkyl group or a derivative thereof further substituted on the phenyl moiety by a sulphamoyl or sulphonylamino group or by a nitro, amino or acetamido group. These particular compounds are useful in therapy as highly effective anti-arrhythmic agents and therefore, are of value in the treatment of various cardiac arrythmias. The most preferred member compound of the series is N-{4-[1-hydroxy-2-(4-[4-pyridinyl]-1-piperazinyl)ethyl]phenyl} methanesulphonamide. Methods for preparing all these compounds from known starting materials are provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.